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We are part of the Sartorius Stedim Biotech Group, a global provider of laboratory and pharmaceutical equipment.
Based near Cambridge UK, we specialise in the design and manufacture of automated cell culture and fermentation systems for the bio-pharma, regenerative medicine and industrial biotechnology sectors, focusing on:
• Bioprocess development • Cell therapy & stem cell research
• GMP manufacture of biologics • Discovery research
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Recombinant adeno-associated virus (rAAV) has shown great promise as a gene therapy vector in multiple aspects of preclinical, clinical and commercial applications. One remaining challenge is establishing large-scale manufacturing technologies with current good manufacturing practices (cGMP) to yield the purified vector quantities and quality for the expanding clinical and further commercial needs.
Simon Fradin, Head of USP Development at CEVEC Pharmaceuticals GmbH, presents the company's use of ambr® 15 as a scale-down model to accelerate the development and optimization of a robust and scalable process of PEI-based transient transfection of CEVEC's unique human suspension CAP-GT® cells using PlasmidFactory's two Plasmid System for the production of rAAV for gene therapy.
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Royston Office: Tel: +44 (0) 1763 227200 | European Service & Support: Tel: +44 (0) 1763 227333 | US Service & Support: Tel: +1 302 478 9060