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automated cell banking

Automated Cell Banking with Fill-It from Sartorius Stedim TAP

High quality automated cell banking relies on the rapid aseptic preparation of cryovials. Issues exist with standard manual methods as they are prone to variation, place constraints on batch sizes, and repetitive tasks raise operator health concerns.
Automated cell banking using Fill-It as a cryovial processing system overcomes these issues Fill-It is capable of decapping, dispensing and capping multiple cryovials in parallel with minimal operator interaction. Fill-It produces high quality and high viability material in cryovials, improved consistency and shortened process times with the potential to increase batch sizes for cell banking and dramatically reduce QC costs.
Fill-It enables the rapid creation of high quality, consistent stock vials in automated cell banking for centralised cell line libraries, screening operations or GMP production cell banks and can be used with both mammalian and microbial cell suspensions. The system may also be used for the rapid dispensing of other biological and non-biological liquids into screw top vials.
cell banking with  Fill-It
Fill-It - Key Features
A key limitation on the size of a batch of cryovials for automated cell banking is how much cell suspension can be processed before the quality is unduly affected by the toxic effects of cryopreservative. The faster, more efficient processing offered by Fill-It allows cell banks to be created in a shorter period of time. This also leads to the possibility of creating larger cell banks within the safe time limit for cell exposure to cryopreservation buffers. Automated cell banking within a single process rather than multiple smaller runs means that cell bank QC costs are reduced so leading to significant cost savings and a rapid return on investment.
Fill-It offers:
  • Automated cell banking
  • Automatically decaps, fills and recaps screw-cap microtubes held in
    96, 48 and 24-way racks
  • Compatible with Nunc, Matrix, Corning and Greiner microtubes
  • Automated tube rack transport system ensures easy loading and operation
  • Sterile disposable tube-set providing the fluid path
  • Fits within a standard laboratory tissue culture cabinet
  • Simple user interface to minimise validation requirements and training procedures
  • Weight 67kg (148 lb)
  • External dimensions 750 mm x 320 mm x 500mm
Fill-It - Key Benefits
Fill-It works straight 'out of the box', automated dispensing to screw cap cryovials is achieved with minimal set up and training. It is an extremely flexible system designed for a wide range of cell supply vessels and cell production strategies.
  • Consistent, high quality cell stock vials
  • Increased batch sizes and reduced QC overhead
  • Reduced risk of repetitive strain injury (RSI)
  • Helps maintain sample integrity due to lower risk of contamination when compared to manual processing
For more information on automated cell banking with Fill-It
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