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bioprocessing automation - ambr

Bioprocessing automation - ambr from Sartorius Stedim TAP.
Mimic classical bioreactors at microscale.

ambr 15® is a new system designed to mimic mammalian cell culture in bioreactors at microscale (10 – 15mL). It has been optimised to reproduce suspension culture conditions that exist within experimental 5 and 10L bioreactors so that comparable results can be obtained rapidly and at much lower cost.
Unlike plate based systems, bioprocessing automation with ambr allows individual control of the environmental conditions as well as feeding and sampling. 24 disposable micro bioreactors can be controlled with an automated workstation to enable a wide range of cell line selection and development experiments to be run. The system can be used to compare multiple clones to select for stability and productivity or multiple replicates of the same clone to compare different feeding strategies and culture conditions on growth and output.
Bioprocessing automation with ambr 15 enables the rapid evaluation of multiple bioreactor cultures at microscale, increasing productivity in cell line development with significant savings on materials and labour.

The new ambr micro bioreactor in detail:

Central to the bioprocessing automation using ambr is the new ambr micro bioreactor – specifically designed to mimic the characteristics of a larger scale bioreactor.
To learn more about the unique design and key features of the ambr micro bioreactor - take an interactive tour.
ambr automated bioprocessing - micro bioreactor 'Interactive Tour'

bioprocessing automation - the ambr microbioreactor

ambr 15 workstation automates:
Following extensive R&D in collaboration with leading bioprocessing automation groups, the first automated ambr 15 workstations are now available – offering parallel processing and evaluation of up to 24 micro bioreactor experiments in an automated bench top system.
  • Closed loop control of pH and DO with independent control of O2 and CO2 for each vessel
  • Automated liquid handling for reactor set-up, feeds, base addition and sampling
  • Easy installation into laminar flow hood allowing aseptic operation
  • Optional integrated viable cell counting
ambr 15 micro bioreactor system offers:
  • A better tool for cell line selection and development - closely mimics the conditions of larger scale bioreactors)
  • Simplified adoption of Quality by Design (QbD) principles for cell culture development
  • Significant reduction in cost per experiment
  • More experiments with less operator time for set up and clean down
Applications include:
  • Automated bioprocessing
  • Cell line stability
  • Cell line selection
  • Media feed strategies
  • Process robustness experimentation in support of ‘quailty by design‘ studies
  • Automation of DOE approaches to process optimisation
ambr 15 micro bioreactor system offers an accurate and cost-effective approach to bioprocessing automation by replicating bioreactor conditions, and can be used as a microscale model for a wide range of upstream processes such as cell line selection and process optimisation.
For more information on ambr 15:
Get more detail on automated bioprocessing - key applications