mini bioreactor - ambr 250 modular ambr 250 modular

Mini bioreactor - ambr® 250 modular - high performance, single-use benchtop bioreactor system for parallel fermentation or cell culture

ambr® 250 modular is a high performance, single-use benchtop mini bioreactor system for parallel fermentation or cell culture.

The system combines bioreactor stations, a control module and software to allow users to set up experiments quickly and easily, enabling them to focus more on the science.

In addition, a fully integrated vessel design eliminates the need for sterilization and reduces the risk of human error.

ambr® 250 modular enables the rapid set up and turnaround of experiments, reducing the time required to complete an experimental campaign.

 

mini bioreactor - ambr 250 modular workstation
ambr® 250 modular - features
  • Control module manages individual vessel requirements including pH, temperature, DO and impeller speed for up to 8 bioreactors
  • Each mini bioreactor has an option of a fully dedicated off-gas analyser measuring both CO2 and O2 and generating CER and OUR data points
  • 3 step "easy connect" vessel installation for all gas, liquid and sensor connections
  • Touch screen user interface enables easy control and supervision of multiple bioreactors
  • Modular, expandable design offers parallel control of 2, 4, 6 or 8 bioreactor experiments to meet the growing needs of your lab.

 

 

ambr® 250 modular vessel - a new concept in single-use mini bioreactors

The vessel is fully integrated with liquid reservoirs and proprietary syringe pumps; and the unit is single use. This innovative design simplifies experimental set-up, significantly reduces manual handling and eliminates the need for vessel sterilization.

  • Fully disposable, single-use 100-250 mL bioreactors
  • Choice of mammalian or microbial vessels with pitch blade or Rushton impeller
  • 5 integrated liquid reservoirs (2 x 125 mL; 3 x 50 mL) with syringe pumps and liquid lines
  • Spot based DO sensor and disposable pH electrode
  • Integrated gas and liquid inlet filters
  • Sparge or headspace gassing options.

Learn more about the revolutionary ambr® 250 modular vessel:

 

 

ambr 250 modular single-use bioreactors
ambr 250 modular mini bioreactor vessel for cell and gene therapies
ambr® 250 modular vessel for cell and gene therapies

The new unbaffled vessel design has a large pitched blade impeller and a working volume of 100-250 mL.

It provides an environment for gentle agitation and mixing without sedimentation, allowing optimal growth of single cell suspensions, cell aggregates or adherent cells on microcarriers.

In trials with leading cell and gene therapy companies, the new mini bioreactor has shown better cell culture performance compared with less predictive spinner or T-flask models, enabling rapid process optimization and improved scalability to larger bioreactors.

The vessel is suitable for:

  • Rapid process development and process optimization
  • HEK293, CAR-T and other therapeutic cell lines
  • Other cultures requiring specialized mixing at slower impeller speed

 

 

ambr® 250 modular - software

ambr® 250 modular is supplied with the same easy-to-use software as the established ambr 250 high throughput system.

For ease of use and multi-tasking, the software has been designed as 4 separate applications:

  • Process definition: Simple “drag and drop” process steps for quick and easy definition of experiments
  • Runtime: Monitoring and adjustment of all process parameters in real time, for each individual bioreactor
  • Results viewer: Comparison of plots from experiments run at different times - allows parameters from multiple experiments to be plotted together on the same graph
  • Experiment viewer: Historical application enables users to fully analyse experiments looking at audit trails, all variables and completed recipes.

All applications enable export and import of data to/from different sources.

ambr® 250 modular - applications

ambr® 250 modular mini bioreactor is configurable for both microbial fermentation and mammalian cell culture and can be used to model a wide range of processes in a variety of applications:

  • Biopharma R&D and process development
  • Industrial biotech R&D and process development
  • MProcess robustness experimentation in support of QbD studies
  • Vaccine process development