| ambr
250® is
a new bioreactor system for small scale
fermentation using single-use bioreactors
controlled by an automated workstation. |
The new system,
developed with two major industrial partners,
builds on our successful microbioreactor
technology, adding increased fermentation
volumes, as well as individual bioreactor
temperature and impeller control.
ambr 250 takes
ambr technology to the next level with a
new platform that adds increased working
fermentation volumes as well as individual
bioreactor temperature and impeller control.
This enhanced environment supports the culture
requirements for both high demand microbial
fermentation and applications where larger
sample volumes are required. |
| The aim of the
ambr 250 development is to provide small
scale fermentation system which changes
the way fermentation process development
is performed. |
| The system
design enables: |
- Set-up and inoculation of up to 24
bioreactors in a single day with less
than 1 FTE
- Rapid turnaround reducing the ‘down-time’
of capital equipment
- Sufficient capacity for 2 factorial
DOE experiments in a single system run.
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| New,
single use 100-250ml reactor
vessels have been developed
for use with the system
– avoiding the need
to clean reactors and
sensors between runs.
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| The
design includes a
novel “easy connect”
process enabling
all gas, liquid and sensor
connections to be made,
quickly and simply, for
fast turnaround between
experiments. |
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| The ambr 250
workstation in detail |
| ambr
250 workstation offers independent,
parallel control of 12 or 24 single-use
bioreactors (100-250 ml working volume). |
- Fully automated small scale fermentation
system, including - media fill, inoculation,
sampling and feeding
- Fully specified disposable mini bioreactor
- Individual control for each bioreactor
vessel - temperature, impeller speed,
pH and DO
- An individual set of four pumped lines
for every bioreactor station
- Integrated control of multiple bioreactors
(12 or 24)
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| ambr 250
offers: |
- Microbial or mammalian culture
- Automated set-up, seeding and sampling
- A better tool for process development
of microbes
- Rapid evaluation of a wide range of
conditions and cell line/strain performance
- Excellent scalability to large-scale,
bench top bioreactors
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| Applications
include: |
- Process development
for biopharma and industrial biotech
- Process robustness experimentation
in support of QbD studies
- Automation of DOE approaches
to process automation
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| For
more information on ambr 250: |
| Get more
detail on small
scale fermentation system - key applications
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