Ambr® 250 High Throughput is a fully automated bioreactor system for parallel fermentation or cell culture using 100-250mL single-use bioreactors controlled by an automated liquid handling platform.
The system provides a high precision environment that supports the demands of microbial fermentation and mammalian cultures.
Ambr® 250 High Throughput provides a rapid and reliable scale-down model to explore a wide range of conditions with excellent scalability to larger bioreactors.
Ambr® 250 High Throughput workstation offers independent, parallel control of 12 or 24 single-use bioreactors (100-250ml working volume).
Single use 100-250ml bioreactor vessels have been developed for use with the system - avoiding the need to clean reactors and sensors between runs.
The design includes a novel "easy connect" process enabling all gas, liquid and sensor connections to be made, quickly and simply, for fast turnaround between experiments.
A range of integrated cell culture analysers are available for the Ambr® 250 High Throughput system.
The new vessel type has been developed to support microcarrier and other cultures requiring specialized mixing capabilities.
The vessel is unbaffled and has a single 'elephant ear' shaped impeller which is larger than the standard 'pitched blade' impeller. The configuration minimizes shear stress. and performs a radial mix of cultures at lower stirring speeds while maintaining cell functionality and other quality aspects. The vessel is suitable for:
This technology integration providesfurther step forward in advanced microbial process monitoring and control:
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Ambr® 250 High Throughput articles
Bioresearch Online White Paper
"Accelerate Your Process Development With High-Throughput, Single-Use, Fully Automated Bioreactors."
"Reducing Biomanufacturing Bottlenecks: Scale-Down Reactor Automates Parameter Control and Facilitates Development."
Cell Culture Dish blog article
"A High Throughput, Scalable Solution to Upstream Process Development." by Dr. Simon Dewar & Dr. Fern Slingsby, FUJIFILM Diosynth Biotechnologies."