ambr® 250 high throughput is a fully automated bioreactor system for parallel fermentation or cell culture using 100-250mL single-use bioreactors controlled by an automated liquid handling platform.
The system provides a high precision environment that supports the demands of microbial fermentation and mammalian cultures.
ambr 250 high throughput provides a rapid and reliable scale-down model to explore a wide range of conditions with excellent scalability to larger bioreactors.
ambr 250 high throughput workstation offers independent, parallel control of 12 or 24 single-use bioreactors (100-250ml working volume).
Single use 100-250ml bioreactor vessels have been developed for use with the system - avoiding the need to clean reactors and sensors between runs.
The design includes a novel "easy connect" process enabling all gas, liquid and sensor connections to be made, quickly and simply, for fast turnaround between experiments.
A range of integrated cell culture analysers are available for the ambr 250 high throughput system.
The new vessel type has been developed to support microcarrier and other cultures requiring specialized mixing capabilities.
The vessel is unbaffled and has a single 'elephant ear' shaped impeller which is larger than the standard 'pitched blade' impeller. The configuration minimizes shear stress. and performs a radial mix of cultures at lower stirring speeds while maintaining cell functionality and other quality aspects. The vessel is suitable for:
This technology integration providesfurther step forward in advanced microbial process monitoring and control:
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Latest technical notes & bibliography
View further information and request copies of the latest ambr 250ht technical notes and bibliography.
ambr 250 high throughput articles
Bioresearch Online White Paper
"Accelerate Your Process Development With High-Throughput, Single-Use, Fully Automated Bioreactors."
"Reducing Biomanufacturing Bottlenecks: Scale-Down Reactor Automates Parameter Control and Facilitates Development."
Cell Culture Dish blog article
"A High Throughput, Scalable Solution to Upstream Process Development." by Dr. Simon Dewar & Dr. Fern Slingsby, FUJIFILM Diosynth Biotechnologies."
View video of the key ambr 250 high throughput workstation processes.
"Using ambr 250 for rapid process improvement and effective scale-up to cGMP manufacture of biotherapeutics" by Fern Slingsby at Fujifilm Diosynth Biotechnologies