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Add-On Capability for pH Calibration and Raman Spectroscopy for Ambr® Bioreactors

The analysis module provides add-on capability for at-line measurement of pH and optionally, Raman spectroscopy, for Ambr® 15 and Ambr® 250 High Throughput bioreactors. The pH measurement automates initial bioreactor vessel pH sensor calibration and subsequent in-process re-calibration, and eliminating the operator time needed for manual offline pH measurement, data transfer and bioreactor pH sensor recalibration.

BioPAT® Spectro in Ambr®

The BioPAT® Spectro Raman spectroscopy flow cell enables integration of 3rd party BioPAT® Spectro-specific Raman spectroscopy probes and data flows from Kaiser Optical Systems and Tornado Spectral Systems.

Advantages of the technology:

Automated data consolidation and contextualization of all spectral and process data into a SIMCA®-ready file for model building
Ambr®-built models are more robust due to the use of all process data and a big DoE design space
Ambr® can execute SIMCA® models to predict analyte concentrations

Ambr® Analysis Module benefits

Enables full automation of sample handling and assay read
Integration of 3rd party Raman spectroscopy probes and data flows
Frequent, accurate pH sensor recalibration
Reduces CO2 outgassing effects and errors compared to manual offline pH samples
User replaceable sensors (electrodes), Raman flow cells, and reagent kits
Reagent kits including calibration solutions, cleaning solutions and a waste container

Operation of the analysis module is supported by user replaceable sensors (electrodes), Raman flow cells, and reagent kits including calibration solutions, cleaning solutions and a waste container.

You can use the Ambr® Analysis Module together with:

Ambr® 15 Cell Culture Generation 2

Ambr® 15 Fermentation

Ambr® 250 High Throughput

Ambr® 250 High Throughput Perfusion

The Analysis Module is suitable for use with both cell culture and microbial media, however is unsuitable for particulates, highly viscous sample or high cell density perfusion cultures.

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